"Can't Leave 'em Alone" is a R&B song recorded by American singer Ciara and rapper 50 Cent for Ciara's second album, Ciara: The Evolution (2006). Written by Ciara, LaShawn Daniels, Rodney Jerkins, and 50 Cent, it is the fourth release and official third single from the album (see 2007 in music). It was solicited to Mainstream Urban radio stations on June 12, 2007 and Rhythmic stations on July 10, 2007.
The song is a 1980s-inspired mid-tempo ballad, featuring the 808 drums. Ciara described it as a "big record", and said that she invited 50 Cent for "some kind of flavor". It was originally titled "Dope Boys".